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жизни организма. Как правило, такие особи нежизнеспособны, но при сохранении функциональности внутренних органов имаго являются жизнеспособными.
При применении ручного лобзика, как правило, пользуются трехслойной фанерой, толщиной до девяти миллиметров.
При регенерации хвостового
плавника Данио-рерио наблюдается целый комплекс процессов восстановления –
восстанавливаются: эпидермис, кости,
мышцы, кровеносные сосуды, нервы.
У аквариумной рыбки Данио-рерио (zebrafish), по крайней мере,
два таких фактора – (Oct4 и Sox2) необходимы для нормальной регенерации хвостового плавника ( ).
Помимо активации определенных генов,
для регенерации необходимо создать особые условия.
Так, например, активируется синтез транскрипционного фактора Lin 28, ген которого в
сочетании с генами Oct4, Sox2 и Nanog используется для
перепрограммирования фибробластов в ИПСК
( ). Интересно отметить, что Lin28
кодирует цитоплазматический мРНК – связывающий белок ( ),
который, связываясь с мРНК кодирующей инсулиноподобный ростовой фактор
2 (Insulin-like growth factor 2 – IGF2) активирует ее
трансляцию ( ). Кроме того Lin28 блокирует созревание let-7 микроРНК в эмбриональных стволовых клетках мыши ( ).
Показано, что при регенерации повышается синтез факторов плюрипотентности (Sox2, Klf4, и c-myc) в регенерирующих конечностях и хрусталике тритона
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