Este fármaco, en contra de lo que se pensaba, actúa sobre la retina (3) inhibiendo la FDE-6 esencialmente en los segmentos externos de los conos y bastones, lo que produce aumento de GMPc retiniano de forma prolongada dañando los fotoreceptores, por tanto viagra podría no estar indicada en los pacientes con retinitis pigmentosa sobre todo si tienen defectos en el gen de la fosfodiesterasa tipo 6 que produce retinitis pigmentosa.
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